Answer: -Drain cleaner is designed for this purpose, and it works well on hair. Drain cleaner is usually sodium hydroxide (strong base). You want to keep it out of your eyes if you value your sight. -Concentrated lye plus oxidizing agent and heat. Drano uses nitrate, but putting solids down a clogged drain can cause problems of its own. It has been displaced by strong hypochlorite in lye plus fumed silica thickener. -Calcium sulphides also dissolve hair. They are used in hair removing creams, but for drains the drain opener (sodium hydroxide with aluminium beads) is the best solution, but it takes atleast 30 minutes or so for complete cleaning.